|
KMID : 0043320140370070916
|
|
Archives of Pharmacal Research
2014 Volume.37 No. 7 p.916 ~ p.926
|
|
|
Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study
|
|
Ali Gowhar
Subhan Fazal
Islam Nazar Ul
Ullah Nasir
Shahid Muhammad
Ullah Sami
Ullah Ihsan
Shah Rehmat
Khan Ikhtiar
Sewell Robert D. E.
Abbas Ghulam
|
|
|
Abstract
|
|
|
|
The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.
|
|
|
KEYWORD
|
|
|
[1-(2-hydroxybenzyl)piperidiniumchloride], [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride], Acetylsalicylic acid, Ulcerogenicity, Gastric juice analysis, Histology
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|